BMP-ID Stress Response
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include YBX3 (Y-box binding protein 3, transcriptional/translational regulator, stress response), MUC4 (mucin 4, epithelial barrier/glycoprotein), PNN (pinin, desmosome-associated RNA splicing), HNRNPU (heterogeneous nuclear ribonucleoprotein U, RNA processing), DDX17 (DEAD-box RNA helicase, splicing/transcription), ID1 and ID2 (inhibitors of differentiation, BMP targets, anti-differentiation), HSPA1A (heat shock protein 70, stress chaperone), NKTR (NK-tumor recognition protein), MT1G (metallothionein, metal stress/oxidative stress). The combination of ID1/ID2 (BMP signaling effectors that maintain undifferentiated state), HSPA1A (stress chaperone), MT1G (oxidative/metal stress), and YBX3 (stress-responsive RNA regulator) suggests a stress-associated dedifferentiation or BMP-responsive program. The significant decrease with UC inflammation is consistent with loss of homeostatic BMP signaling in inflamed colon macrophages.
Genes
Most correlated modules
- RNA Processing Translation · correlation 0.98
- Macrophage Transcriptional Regulation · correlation 0.98
- Proteasome & Apoptosis · correlation 0.97
- Hypoxia Response Regulation · correlation 0.97
- Macrophage Identity Adhesion · correlation 0.97
- Inflammatory Lipid Metabolism · correlation 0.96
- Desmosomal Adhesion · correlation 0.90
- Housekeeping Metabolism · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.