Macrophage Phagocytic
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: ANXA11 (annexin XI, calcium-dependent membrane binding), IL2RG (common gamma chain of cytokine receptors - immune cell marker), STAP2 (signal transducing adaptor in cytokine signaling), ARPC5 (Arp2/3 complex, actin branching), ATP6V0B (V-ATPase subunit, lysosomal acidification), TALDO1 (transaldolase, pentose phosphate pathway), VAMP8 (vesicle-associated membrane protein, exocytosis/phagocytosis), CAPG (actin capping protein, macrophage motility), OAZ1 (ornithine decarboxylase antizyme, polyamine regulation), MSRB2 (methionine sulfoxide reductase, antioxidant), UBXN1 (ubiquitin regulatory). IL2RG and STAP2 suggest cytokine receptor signaling; CAPG and ARPC5 suggest actin-based motility; VAMP8 and ATP6V0B suggest vesicular/lysosomal activity. This combination is consistent with macrophage phagocytic and cytokine-responsive housekeeping.
Genes
Most correlated modules
- Endosomal Vesicle Trafficking · correlation 0.99
- Epithelial Identity · correlation 0.99
- Inflammatory Myeloid · correlation 0.99
- Autophagy Lysosomal · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Actin Cytoskeletal Regulation · correlation 0.98
- Metabolic Detoxification · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.