Inflammatory Myeloid
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
TMEM176B is a lysosomal/endosomal membrane protein strongly expressed in macrophages and dendritic cells, known to regulate inflammasome activation and antigen presentation; it is upregulated in inflammatory conditions. HNMT (histamine N-methyltransferase) metabolizes histamine and is expressed in intestinal epithelial and immune cells. PLBD1 (phospholipase B-like 1) is a lysosomal enzyme involved in lipid metabolism, expressed in myeloid cells. AKR1C3 (aldo-keto reductase 1C3) is involved in steroid and prostaglandin metabolism, upregulated in inflammation. RNASE1 is an RNase expressed in intestinal epithelium and macrophages. FAM3C is a cytokine-like protein. ATP6V0E1 is a V-ATPase subunit (lysosomal). PPIC (cyclophilin C) is involved in protein folding. CSRP2 (cysteine and glycine-rich protein 2) is a LIM domain protein. FAM162A is involved in hypoxia response. The module is significantly upregulated in both UC and CD inflammation, consistent with an inflammatory macrophage/myeloid program involving lysosomal activity and inflammatory mediator metabolism.
Genes
Most correlated modules
- Macrophage Phagocytic · correlation 0.99
- Lysosomal Lipid Catabolism · correlation 0.99
- Macrophage Homeostasis · correlation 0.98
- ER Redox Homeostasis · correlation 0.98
- Endosomal Vesicle Trafficking · correlation 0.98
- WNT-BMP Morphogenic · correlation 0.97
- Autophagy Lysosomal · correlation 0.97
- Non-canonical NF-κB · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.