Protein Processing ER
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include CACYBP (calcyclin-binding protein, involved in ubiquitination/proteasome targeting), TMED2 (COPI vesicle/ER-Golgi trafficking), CCT6A (chaperonin complex subunit), TKT (transketolase, pentose phosphate pathway), MRPL13 (mitochondrial ribosomal protein), RTN4 (reticulon, ER shaping), HNRNPR (RNA binding/splicing), SLC44A1 (choline transporter), AK3 (adenylate kinase, mitochondrial), PDIA6 (protein disulfide isomerase, ER folding). The module combines ER protein processing (TMED2, RTN4, PDIA6), chaperone (CCT6A), RNA processing (HNRNPR), mitochondrial (MRPL13, AK3), and metabolic (TKT) functions. Uniform expression, all core, decreased in inflammation — housekeeping. The ER/protein folding components (PDIA6, TMED2, RTN4, CCT6A) are prominent, suggesting protein processing emphasis.
Genes
Most correlated modules
- Nuclear Transport RNA · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Protein Homeostasis · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- ER Membrane Trafficking · correlation 0.99
- Metabolic Housekeeping · correlation 0.98
- DNA Damage Response · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.