DNA Damage Response
Gene co-expression module in Microfold-like cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include PDCD6IP (ALIX, ESCRT/apoptosis), RAD21 (cohesin subunit, DNA repair and chromatin organization), XRCC5 (Ku80, non-homologous end joining DNA repair), ARL6IP1 (ER morphology/apoptosis), RALA (RAS-like GTPase, vesicle trafficking), CDH1 (E-cadherin, epithelial adhesion), and RBM47 (RNA-binding). RAD21 and XRCC5 are strong DNA repair anchors. The module appears to combine DNA damage response with vesicle trafficking and adhesion, but DNA repair genes are the most functionally coherent subset among hubs.
Genes
Most correlated modules
- Protein Homeostasis · correlation 0.99
- ER Membrane Trafficking · correlation 0.99
- Apoptosis Regulation · correlation 0.99
- Protein Processing ER · correlation 0.98
- Actin & Membrane · correlation 0.98
- Membrane Remodeling mTOR · correlation 0.98
- Nuclear Transport RNA · correlation 0.98
- Metabolic Housekeeping · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.