Housekeeping Mixed
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include RAN (GTPase for nuclear transport), LSM4/LSM3 (Sm-like proteins, RNA splicing/processing), SLC25A5 (mitochondrial ADP/ATP translocase), PRDX1 (peroxiredoxin, antioxidant), UQCRFS1 (complex III subunit), MRPL51 (mitochondrial ribosomal protein), DYNLT1 (dynein light chain), SYPL1 (synaptophysin-like), NDUFA9 (complex I subunit), PSMA4 (proteasome), XRCC6 (DNA repair/Ku70), SRP9 (signal recognition particle). This module mixes mitochondrial OxPhos (UQCRFS1, NDUFA9, SLC25A5, MRPL51), RNA splicing (LSM4, LSM3, SRP9), nuclear transport (RAN), and proteasome (PSMA4). The pattern is consistent with a broad housekeeping/cellular maintenance module. Neighbor context confirms housekeeping cluster. The mitochondrial components are notable but not dominant enough to call this purely OxPhos.
Genes
Most correlated modules
- ER & Mitochondrial Maintenance · correlation 1.00
- Mitochondrial OxPhos · correlation 0.99
- Protein Processing ER · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Mitochondrial OxPhos · correlation 0.99
- Protein Homeostasis · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.