ER Membrane Trafficking
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PGRMC1 (ER membrane progesterone receptor), TMED10 (p24 family ER-Golgi cargo receptor), KDELR2 (ER retention receptor), HSD17B12 (ER-resident fatty acid elongase/steroid enzyme), and CHMP2B (ESCRT-III endosomal sorting) collectively define ER membrane identity and trafficking. CD59 (GPI-anchored complement regulator) and ANXA4 (membrane-associated annexin) add membrane biology context. KRAS links to membrane-associated RAS signaling. The module represents ER membrane organization and vesicular trafficking.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.99
- Protein Homeostasis · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- DNA Damage Response · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
- Membrane Trafficking · correlation 0.99
- Organelle Homeostasis · correlation 0.99
- Protein Processing ER · correlation 0.99
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.