Mitochondrial OxPhos
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include COX6C and COX5B (cytochrome c oxidase subunits, Complex IV), UQCRB (ubiquinol-cytochrome c reductase, Complex III), NDUFA1 (NADH dehydrogenase, Complex I) — all mitochondrial respiratory chain components. Additional genes: TPT1 (TCTP, translation/growth), RACK1 (ribosome scaffold), ACTG1 and ACTB (actin cytoskeleton), MYL6 (myosin light chain), HLA-B (MHC class I), C15orf48 (mitochondria-associated), SH3BGRL3 (thioredoxin-like), PIGR (polymeric immunoglobulin receptor, epithelial), FTL (ferritin light chain, iron storage). The module has very high mean expression (2.302) and detection rate (93.7%), consistent with housekeeping/constitutive expression. The mitochondrial OxPhos genes (COX6C, COX5B, UQCRB, NDUFA1) are the most coherent hub genes. The module decreases slightly with inflammation and recovers with CD treatment, consistent with a constitutive metabolic program suppressed during disease. This is a mitochondrial OxPhos/housekeeping module, with additional cytoskeletal and translation components reflecting general cellular activity.
Genes
Most correlated modules
- Cellular Homeostasis · correlation 0.88
- Immediate Early Stress · correlation 0.84
- Metabolic Bioenergetics · correlation 0.75
- Cytoskeletal Contractility · correlation 0.71
- Stem-like Regenerative · correlation 0.68
- Actin-mediated Migration · correlation 0.64
- Metabolic Homeostasis · correlation 0.60
- ER Stress Response · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.