Actin Cytoskeletal Dynamics
Gene co-expression module in Microfold-like cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub genes TMSB4X (actin sequestration) and CFL1 (cofilin-1, actin depolymerization) define an actin cytoskeletal dynamics program. CD63 marks lysosomal/endosomal compartments relevant to macrophage function. S100A11 and S100A6 are calcium-binding inflammatory mediators. CD74 is the MHC II invariant chain involved in antigen presentation. CST3 and SPINT2 are protease inhibitors. LGALS4 and CYSTM1 add epithelial/stress context. The module is mildly upregulated in UC inflammation. In the context of M_like cells, this reflects active cytoskeletal remodeling coupled with lysosomal and antigen-handling activity, consistent with macrophage phagocytic/migratory states.
Genes
Most correlated modules
- Housekeeping Metabolism · correlation 0.90
- Desmosomal Adhesion · correlation 0.81
- RNA Processing Translation · correlation 0.70
- Macrophage Identity Adhesion · correlation 0.63
- BMP-ID Stress Response · correlation 0.63
- Proteasome & Apoptosis · correlation 0.60
- Hypoxia Response Regulation · correlation 0.54
- Inflammatory Lipid Metabolism · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.