Actin & Membrane
Gene co-expression module in Microfold-like cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub genes ARPC4 (Arp2/3 complex actin nucleation) and CAPZB (actin filament capping) are core actin cytoskeletal regulators. ATP6V0D1 (V-ATPase subunit, lysosomal acidification), SPPL2A (intramembrane protease), RPN1 (ER oligosaccharyltransferase), TSPAN3 (tetraspanin membrane scaffold), and PLGRKT (plasminogen receptor) add membrane/lysosomal biology. ETFA and PGAM1 contribute metabolic housekeeping. The module is mixed but actin dynamics and membrane biology are the dominant theme among hub genes.
Genes
Most correlated modules
- Membrane Remodeling mTOR · correlation 0.99
- Membrane Trafficking · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.99
- Metabolic Housekeeping · correlation 0.99
- Metabolic Housekeeping · correlation 0.98
- ER Membrane Trafficking · correlation 0.98
- ER Redox Homeostasis · correlation 0.98
- Intracellular Cargo Transport · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.