Metabolic Housekeeping
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ILF2 (interleukin enhancer binding factor 2, RNA processing and NF-κB co-activator), POLR2K (RNA polymerase II subunit K, transcription), SEC11C (signal peptidase complex, ER co-translational processing), PPP1CB (protein phosphatase 1 catalytic subunit), MTCH2 (mitochondrial carrier homolog 2, apoptosis/mitochondrial), ACOX1 (peroxisomal acyl-CoA oxidase, fatty acid beta-oxidation), MRPS6 (mitochondrial ribosomal protein), and SDR16C5 (short-chain dehydrogenase, lipid metabolism). The module is mixed but mitochondrial/metabolic genes (MTCH2, ACOX1, MRPS6, ETFA-neighbor) and RNA/transcription machinery (ILF2, POLR2K) dominate. Decreased with CD inflammation and restored with treatment suggests a baseline housekeeping metabolic program suppressed by inflammation.
Genes
Most correlated modules
- ER Membrane Trafficking · correlation 0.99
- Actin & Membrane · correlation 0.99
- Complex I Assembly · correlation 0.99
- Membrane Remodeling mTOR · correlation 0.98
- Organelle Homeostasis · correlation 0.98
- ER Redox Homeostasis · correlation 0.98
- Intracellular Cargo Transport · correlation 0.98
- DNA Damage Response · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.