Mitochondrial OxPhos
Gene co-expression module in Microfold-like cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include NDUFA12, NDUFS3, NDUFA10, NDUFA6 (NADH dehydrogenase/complex I subunits), SLIRP (mitochondrial RNA processing), SNRPF (snRNP splicing), AKR7A2 (aldo-keto reductase, detoxification), TXN (thioredoxin, redox), LSM7 (Sm-like, RNA splicing), SDHD (succinate dehydrogenase complex II), DDT (D-dopachrome tautomerase, macrophage migration inhibitory factor family). The module is dominated by mitochondrial complex I subunits (NDUFA12, NDUFS3, NDUFA10, NDUFA6) and complex II (SDHD), with mitochondrial RNA processing (SLIRP) and redox (TXN). This is a tightly defined OxPhos/mitochondrial electron transport module. Decreased in inflammation, restored by CD treatment. Neighbor M54 is also OxPhos-dominant, confirming the neighborhood.
Genes
Most correlated modules
- Housekeeping Mixed · correlation 0.99
- Mitochondrial OxPhos · correlation 0.99
- RNA Processing Homeostasis · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- ER Cotranslational Processing · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
- Translation Initiation · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.