Translation Initiation
Gene co-expression module in Microfold-like cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include EIF3F, EIF3E, EIF3D, EIF3L (eukaryotic initiation factor 3 subunits, translation initiation complex), EIF4B (translation initiation factor 4B), COX7A2L (cytochrome c oxidase assembly factor/supercomplex assembly), NDUFB5 (NADH dehydrogenase complex I subunit), and GPR160 (orphan GPCR). The module is dominated by eIF3 complex subunits (EIF3F, EIF3E, EIF3D, EIF3L) and EIF4B, making translation initiation the primary program. COX7A2L and NDUFB5 link to mitochondrial function, consistent with the neighborhood. Uniform expression, all core, decreased in inflammation and restored by CD treatment — housekeeping translation machinery. The eIF3 complex is the most prominent feature.
Genes
Most correlated modules
- ER Cotranslational Processing · correlation 1.00
- Mitochondrial OxPhos · correlation 0.99
- Organelle Homeostasis · correlation 0.99
- ER & Mitochondrial Maintenance · correlation 0.99
- Housekeeping Mixed · correlation 0.99
- Proteasome Proteolysis · correlation 0.99
- OxPhos Complex IV · correlation 0.99
- Housekeeping Mixed · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.