AP-1 Hypoxia Response
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub genes are IER2 (immediate early gene), JUNB (AP-1 transcription factor, immediate early), SOX4 (transcription factor, stemness/stress), VEGFA (hypoxia/angiogenesis response), NR4A1 (nuclear receptor, immediate early/stress), HSPA1B (heat shock protein, stress), BTG2 (anti-proliferative, stress), FOSB (AP-1, immediate early), JUND (AP-1), HES1 (Notch target, stemness), ELF3 (ETS transcription factor, epithelial), CLDN4 (claudin, tight junction), PNISR (splicing), RRBP1 (ER membrane), FUS (RNA binding), DDX3X (RNA helicase). This module is dominated by AP-1 immediate early transcription factors (JUNB, FOSB, JUND, IER2, NR4A1, BTG2) alongside stemness/differentiation factors (SOX4, HES1) and a hypoxia marker (VEGFA). It is a neighbor of M46 which also has AP-1/immediate early genes. Together these two modules represent overlapping immediate early gene programs; M74 is distinguished by the additional presence of stemness (SOX4, HES1) and hypoxia (VEGFA) components, suggesting it captures a stress-induced dedifferentiation or hypoxia-associated immediate early response in M-like cells.
Genes
Most correlated modules
- ER Stress Response · correlation 0.95
- Integrated Stress Response · correlation 0.55
- Metabolic Homeostasis · correlation 0.55
- ER Stress Response · correlation 0.52
- Actin-mediated Migration · correlation 0.50
- Stem-like Regenerative · correlation 0.46
- Inflammatory Lipid Metabolism · correlation 0.45
- Macrophage Transcriptional Regulation · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.