ER Stress Response
Gene co-expression module in Microfold-like cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include TMEM14C (mitochondrial inner membrane protein), HSPA9 (mortalin, mitochondrial HSP70), APP (amyloid precursor protein, membrane trafficking/signaling), CSTB (cystatin B, protease inhibitor), KLF10 (TGF-β-inducible Krüppel-like factor, anti-proliferative/stress), ARHGAP26 (Rho GAP), SPCS1 (signal peptidase complex, ER), MTUS1 (microtubule-associated tumor suppressor), SERP1 (stress-associated ER protein), SULF2 (heparan sulfate sulfatase, ECM remodeling), CD99 (cell adhesion/migration), DDX5 (RNA helicase), PHLDA2 (pleckstrin homology domain, stress/apoptosis), SRSF3 and HNRNPK (RNA splicing), CLDN3 (claudin, tight junction), CFLAR (c-FLIP, apoptosis inhibitor). The module shows mild upregulation with inflammation and partial recovery with remission. The combination of ER stress proteins (SERP1, SPCS1, HSPA9), RNA processing (DDX5, SRSF3, HNRNPK), anti-apoptotic (CFLAR), and tight junction (CLDN3) genes suggests a mixed ER/RNA processing and epithelial integrity program. The ER stress and RNA processing components are most coherent; the module likely reflects a baseline ER homeostasis and RNA surveillance program in M-like/epithelial cells.
Genes
Most correlated modules
- AP-1 Hypoxia Response · correlation 0.95
- Inflammatory Lipid Metabolism · correlation 0.56
- Macrophage Transcriptional Regulation · correlation 0.54
- Proteasome & Apoptosis · correlation 0.50
- Hypoxia Response Regulation · correlation 0.50
- Metabolic Homeostasis · correlation 0.49
- ER Stress Response · correlation 0.49
- Actin-mediated Migration · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.