Interferon NK Activation
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
IFITM1 is a canonical interferon-stimulated gene mediating antiviral defense. KLRK1 (NKG2D) is the primary activating receptor on NK cells, upregulated by interferon signaling. RNASEK participates in viral entry restriction. CYRIB regulates Rac1-driven actin dynamics downstream of activating signals. UBE2V1 is involved in NF-κB and DNA damage ubiquitin signaling. The combination of IFITM1 and KLRK1 strongly suggests interferon-driven NK cell activation. Mild upregulation in both UC and CD inflammation supports an inflammatory context.
Genes
CYRIB, IFITM1, KLRK1, NHERF1, PLAAT4, RNASEK, SEPTIN9, TLE5, UBE2V1
Most correlated modules
- Mitochondrial Membrane Organization · correlation 0.95
- Septin Cytoskeletal Assembly · correlation 0.88
- Histone Variant Remodeling · correlation 0.81
- NK Activation Signaling · correlation 0.73
- Housekeeping Mixed · correlation 0.72
- Replication-Coupled Histones · correlation 0.65
- NK Degranulation Activation · correlation 0.58
- NK Cell Identity · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.