Mitochondrial Membrane Organization
Gene co-expression module in Natural Killer cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
ATP5MK and ATP5MJ are subunits of mitochondrial ATP synthase (Complex V). TOMM6 is a component of the TOM complex for mitochondrial protein import. MICOS10 is part of the mitochondrial contact site and cristae organizing system. PHB1 (Prohibitin-1) is an inner mitochondrial membrane scaffold critical for cristae integrity and respiratory chain assembly. GABARAP participates in mitophagy. Together these genes define mitochondrial inner membrane organization and oxidative phosphorylation. Flat disease response suggests a housekeeping mitochondrial program.
Genes
ATP5MJ, ATP5MK, BBLN, CIAO2B, GABARAP, H3-3A, MICOS10, PHB1, SEPTIN7, TOMM6
Most correlated modules
- Septin Cytoskeletal Assembly · correlation 0.95
- Interferon NK Activation · correlation 0.95
- Histone Variant Remodeling · correlation 0.89
- Housekeeping Mixed · correlation 0.76
- Replication-Coupled Histones · correlation 0.70
- NK Activation Signaling · correlation 0.63
- Actin Cytoskeleton Remodeling · correlation 0.54
- NK Degranulation Activation · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.