NK TGF-β Regulation
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
NCR1 (NKp46) is a canonical NK cell activating receptor and defining NK marker. TNFRSF1A (TNFR1) mediates inflammatory TNF signaling. TGFBR2 encodes TGF-β receptor II, linking NK cells to immunosuppressive TGF-β signaling in the intestinal microenvironment. PTPN6 (SHP-1) is an inhibitory phosphatase regulating NK activation thresholds. GIMAP5 supports lymphocyte survival. SASH3 and CSK regulate immune receptor signaling. Upregulated in CD inflammation, this module reflects NK cell identity with integrated inhibitory/TGF-β regulatory signaling.
Genes
AOAH, CSK, GIMAP5, NCR1, PPP1R18, PTPN6, PYCR2, SASH3, TGFBR2, TNFRSF1A
Most correlated modules
- NK Lymphocyte Survival · correlation 0.72
- Actin Cytoskeleton Remodeling · correlation 0.54
- NK Cytotoxic Activation · correlation 0.54
- Interferon NK Activation · correlation 0.50
- NK Maturation Program · correlation 0.49
- NK Cell Identity · correlation 0.44
- Septin Cytoskeletal Assembly · correlation 0.39
- Mitochondrial Membrane Organization · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.