Housekeeping Mixed
Gene co-expression module in Natural Killer cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
H2AJ and H3-3B are replication-independent histone variants, linking this module to the histone neighborhood (M37, M87). ATP6V0C is a vacuolar H+-ATPase subunit involved in lysosomal acidification and granule exocytosis. PNPLA2 (ATGL) is the rate-limiting triglyceride lipase. TARS3 is mitochondrial threonyl-tRNA synthetase. MARCHF3 is an E3 ubiquitin ligase. The module is mixed but the histone variants and vacuolar ATPase suggest a chromatin/vesicle housekeeping program. Low disease response supports a baseline housekeeping role.
Genes
ATP6V0C, ENSG00000285976, H2AJ, H3-3B, MARCHF3, NCBP2AS2, PNPLA2, PRXL2C, TARS3, ZNRD2
Most correlated modules
- Septin Cytoskeletal Assembly · correlation 0.80
- Mitochondrial Membrane Organization · correlation 0.76
- Interferon NK Activation · correlation 0.72
- Inflammatory Stress Response · correlation 0.67
- TGF-beta Response · correlation 0.63
- Replication-Coupled Histones · correlation 0.59
- Histone Variant Remodeling · correlation 0.58
- NK/ILC Differentiation · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.