Histone Variant Remodeling
Gene co-expression module in Natural Killer cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes H2AZ1, H2AZ2, MACROH2A1, and H2AX are all histone H2A variants involved in replication-independent chromatin remodeling and DNA damage response. C17orf49 is a histone chaperone. PSMA6/PSMB10 are proteasome subunits that process histones. The module is upregulated in CD inflammation and reduced in remission, consistent with chromatin remodeling during inflammatory activation. Neighbor modules M87 and M47 also contain histones, confirming a chromatin neighborhood.
Genes
ARF5, C17orf49, DDOST, GNB2, H2AX, H2AZ1, H2AZ2, IFT25, MACROH2A1, PSMA6, PSMB10
Most correlated modules
- Mitochondrial Membrane Organization · correlation 0.89
- Replication-Coupled Histones · correlation 0.82
- Interferon NK Activation · correlation 0.81
- Septin Cytoskeletal Assembly · correlation 0.80
- Replication Histones · correlation 0.68
- Actin Cytoskeleton Remodeling · correlation 0.68
- S-phase Replication · correlation 0.65
- Mitotic Spindle · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.