Circadian Apoptotic Priming
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
NR1D2 (REV-ERBβ) is a nuclear receptor and core circadian clock repressor, linking this module to the circadian theme seen in neighbor modules M43 (CRY1/NOCT) and M82 (PER1). TNFSF8 (CD153/CD30L) is a TNF superfamily ligand expressed on activated NK and T cells. BBC3 (PUMA) is a pro-apoptotic BH3-only protein and p53 target. RNF125 is an E3 ubiquitin ligase that ubiquitinates RIG-I and TRAF6, negatively regulating innate immune signaling. OFD1 is involved in centriole biogenesis. SERPINE2 is a serine protease inhibitor. The module has weaker inflammation association than neighbors and lower coherence. The combination of circadian (NR1D2), apoptosis (BBC3), and innate immune regulation (RNF125, TNFSF8) genes suggests a mixed module, possibly reflecting circadian-regulated apoptotic priming in NK cells.
Genes
BBC3, CORO7, CTDP1, EML4, LDB2, NR1D2, OFD1, RNF125, SERPINE2, TNFSF8
Most correlated modules
- Lymphocyte Trafficking · correlation 0.53
- Inflammatory Stress Response · correlation 0.36
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.