SERPINE2 — Serpin family E member 2
SERPINE2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERPINE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | ABI3BP, ADRA2C, ANXA3, CGNL1, CLIC3, ELN, FBLN2, FGF18 +5 more | View in SCUBA |
| Fibroblasts | Elastin-Fibronectin ECM ECM production | ABI3BP, DDAH2, ELN, FN1, LRIG3, S100A4, SOD3, SSC5D | View in SCUBA |
| Hematopoietic progenitor cells | General Metabolic Housekeeping Housekeeping | ACSM3, DTD1, EREG, FXN, NAA38, SLC39A3, SLC39A8 | |
| Natural Killer cells | Circadian Apoptotic Priming Stress | BBC3, CORO7, CTDP1, EML4, LDB2, NR1D2, OFD1, RNF125 +1 more | View in SCUBA |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NEO1, NID1, PROM1, PSD3, SPON1 +2 more | View in SCUBA |
About the gene
| Synonyms | GDN, nexin, PI7, PN1, PNI |
|---|---|
| Chromosome | 2: 223975045-224039318 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Developmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor |
| Biological process | Differentiation, Neurogenesis |
Function
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.