OFD1 — OFD1 centriole and centriolar satellite protein
OFD1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OFD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Modification DNA/chromatin regulation | AKAP13, CREBRF, EPC1, GCC2, GPBP1, JMJD1C, KMT2E, PPP1R2 +6 more | View in SCUBA |
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | ACAP2, BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB +4 more | View in SCUBA |
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 more | View in SCUBA |
| Gamma-delta T cells | T cell cAMP Signaling TCR Signaling | AP1G2, ATP13A1, CCAR2, CDK9, CNOT3, GSR, LAX1, PDE7A +3 more | |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9 +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, DUSP16, FAS +8 more | |
| Natural Killer cells | Circadian Apoptotic Priming Stress | BBC3, CORO7, CTDP1, EML4, LDB2, NR1D2, RNF125, SERPINE2 +1 more | View in SCUBA |
About the gene
| Synonyms | 71-7A, CXorf5, JBTS10, RP23 |
|---|---|
| Chromosome | X: 13734743-13777955 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.