CORO7 — Coronin 7
CORO7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CORO7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | RNA Splicing m6A RNA processing & translation | ARF1, ARF6, ATP5F1B, CIRBP, EIF1B, EIF5A, EMD, GUK1 +15 more | |
| Natural Killer cells | Circadian Apoptotic Priming Stress | BBC3, CTDP1, EML4, LDB2, NR1D2, OFD1, RNF125, SERPINE2 +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ22021, POD1 |
|---|---|
| Chromosome | 16: 4354542-4425705 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Protein transport, Transport |
Function
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.