Lymphocyte Trafficking
Gene co-expression module in Natural Killer cells
| Category | Homing & TEM |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes P2RY8 (purinergic receptor regulating lymphocyte positioning in lymphoid organs) and S1PR1 (sphingosine-1-phosphate receptor 1, master regulator of lymphocyte egress from lymphoid tissues) together define a lymphocyte trafficking/homing program. LAPTM5 is a lysosomal protein regulating immune cell activation thresholds. PTPRJ is a phosphatase acting as an immune checkpoint. LITAF drives TNF transcription in response to LPS. ORAI1 mediates store-operated calcium entry critical for NFAT-dependent gene expression. BCL6 represses inflammatory gene expression. RNF166 is an E3 ligase involved in endosomal sorting. The module is upregulated in IBD inflammation and reversed by treatment, suggesting altered NK cell trafficking in inflamed intestine.
Genes
BCL6, CTSD, LAPTM5, LITAF, ORAI1, P2RY8, PTPRJ, RNF166, S1PR1, SPOCK2, TSEN54, TUBB2A
Most correlated modules
- Cytoskeletal Remodeling · correlation 0.62
- KIR+ NK Maturation · correlation 0.60
- TGF-beta Response · correlation 0.55
- Circadian Innate Signaling · correlation 0.53
- NK Cell Maturation · correlation 0.53
- Circadian Apoptotic Priming · correlation 0.53
- NK Cell Exhaustion · correlation 0.52
- Cytotoxic NK Maturation · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.