Long-gene nuclear transcripts
Gene co-expression module in Paneth cells
| Category | Technical artifact |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
This module is again dominated by long genes with uniform expression (FGGY, AKAP13, EPB41, SHANK2, NF1, CMIP, LDLRAD4, FOXJ3). IL22RA1 is biologically relevant because IL-22 drives antimicrobial peptide expression in Paneth cells. However, it is a peripheral member, and the module structure mirrors the long-gene artifact neighbors.
Genes
Most correlated modules
- Vesicle trafficking · correlation 0.87
- Granule transport · correlation 0.76
- Crypt progenitor program · correlation 0.73
- Rho GTPase regulation · correlation 0.64
- Chromatin remodeling regulators · correlation 0.62
- Long-gene nuclear transcripts · correlation 0.57
- Na/K-ATPase energetic transport · correlation 0.32
- Regulated granule exocytosis · correlation 0.28
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.