Na/K-ATPase energetic transport
Gene co-expression module in Paneth cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
The module mixes ion transport (ATP1A1, the Na/K-ATPase that drives epithelial transport), the OxPhos subunits UQCRH and ATP5ME, the signaling G-protein GNAS, the actin-sequestering TMSB4X and the epithelial transcription factor ELF3. Coherence is moderate and PTPRG and NAALADL2 have weak membership, so it is a combined program. The shared theme is an energetically demanding epithelial transport/secretory state, with ATPase activity fueled by mitochondrial ATP. It is related to M7's mitochondrial and housekeeping content.
Genes
Most correlated modules
- Abundant housekeeping transcripts · correlation 0.67
- Redox homeostasis · correlation 0.63
- Crypt progenitor program · correlation 0.56
- Translation elongation · correlation 0.54
- Electron transport chain · correlation 0.50
- LGR5+ crypt stemness · correlation 0.50
- Crypt progenitor-absorptive · correlation 0.49
- Chaperone proteostasis stress · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.