Chaperone proteostasis stress
Gene co-expression module in Paneth cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
The module mixes ER chaperones (HSP90B1, PDIA3), a cytosolic chaperone (HSP90AB1), OxPhos genes (COX4I1, ATP5IF1) and an antioxidant (PRDX5). It also contains CD63, S100A6, IFI27, and the quiescence marker CDKN1C. The most coherent theme is a proteostasis/chaperone stress program in highly secretory Paneth cells, with a metabolic component. The ER chaperones have weaker membership, so the module is somewhat mixed. It neighbors the secretory granule module M1.
Genes
Most correlated modules
- Mitochondrial biogenesis · correlation 0.75
- Redox homeostasis · correlation 0.65
- Abundant housekeeping transcripts · correlation 0.63
- Translation elongation · correlation 0.55
- hnRNP mRNA processing · correlation 0.55
- ER secretory load · correlation 0.51
- Electron transport chain · correlation 0.51
- Na/K-ATPase energetic transport · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.