Translation elongation
Gene co-expression module in Paneth cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
The core of this module is translation machinery: elongation factors EEF1A1 and EEF1B2, the ribosome-associated NACA and RACK1, and TPT1, a translation-associated protein. PTMA is a highly abundant proliferation-linked nuclear protein. SPINK1 is a secretory product co-varying with this abundance axis. Together the module represents a translation and ribosome-associated program.
Genes
Most correlated modules
- Translation machinery · correlation 0.91
- Electron transport chain · correlation 0.91
- Mitochondrial biogenesis · correlation 0.84
- Redox homeostasis · correlation 0.82
- ER secretory load · correlation 0.79
- Progenitor-like differentiation · correlation 0.76
- Abundant housekeeping transcripts · correlation 0.68
- Crypt progenitor-absorptive · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.