Electron transport chain
Gene co-expression module in Paneth cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
This module is dominated by electron transport chain subunits: complex III (UQCR10, UQCRQ), complex IV (COX5A, COX5B, COX6A1) and ATP synthase (ATP5MC3). The glycolytic gene GAPDH supports a cellular energy-metabolism program. It clearly reflects oxidative phosphorylation capacity.
Genes
Most correlated modules
- Translation machinery · correlation 0.92
- Translation elongation · correlation 0.91
- Redox homeostasis · correlation 0.88
- Crypt progenitor-absorptive · correlation 0.82
- ER secretory load · correlation 0.82
- Mitochondrial biogenesis · correlation 0.78
- Abundant housekeeping transcripts · correlation 0.77
- Progenitor-like differentiation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.