Chromatin remodeling regulators
Gene co-expression module in Paneth cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
The module is enriched for chromatin remodelers and corepressors. SMARCC1 belongs to the SWI/SNF complex, CHD7 is a chromatin remodeler, and TBL1XR1 is an NCoR/SMRT corepressor that also acts as a WNT/beta-catenin coactivator. SENP6 regulates SUMOylation of chromatin proteins, and ZNF91 is a KRAB zinc-finger repressor. PUM1 and SPIDR are peripheral to this theme. These are also long genes, so nuclear-transcript bias likely contributes.
Genes
Most correlated modules
- Granule transport · correlation 0.82
- Crypt progenitor program · correlation 0.76
- Rho GTPase regulation · correlation 0.73
- Long-gene nuclear transcripts · correlation 0.62
- Chromatin remodeling · correlation 0.52
- Vesicle trafficking · correlation 0.42
- Progenitor-like differentiation · correlation 0.38
- Long-gene nuclear transcripts · correlation 0.32
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.