Mitochondrial biogenesis
Gene co-expression module in Paneth cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
The module mixes mitochondrial OxPhos subunits (ATP5F1E, UQCRB, ATP5MC2), mitochondrial proteostasis genes (HSPD1, CHCHD2) and translation factors (EEF1D, EEF2, YBX1). It also contains cytoskeletal and epithelial genes (KRT8, ACTB) and HLA-B. Expression is uniform. This looks like a general biosynthetic and mitochondrial housekeeping axis, with the mitochondrial genes forming the plurality.
Genes
Most correlated modules
- Translation elongation · correlation 0.84
- Electron transport chain · correlation 0.78
- hnRNP mRNA processing · correlation 0.76
- Chaperone proteostasis stress · correlation 0.75
- Translation machinery · correlation 0.75
- Redox homeostasis · correlation 0.67
- Progenitor-like differentiation · correlation 0.66
- ER secretory load · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.