Progenitor-like differentiation
Gene co-expression module in Paneth cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
SOX4, MARCKSL1, CD24 and H3-3A are features of immature, progenitor-like or early-differentiating crypt epithelial cells. CD24 is also a known Paneth and crypt base marker. XRCC5 and ATP1B1 fit proliferative or progenitor states. The module likely captures a less mature, newly differentiating Paneth or progenitor-like state.
Genes
Most correlated modules
- Translation machinery · correlation 0.92
- Translation elongation · correlation 0.76
- Electron transport chain · correlation 0.74
- Redox homeostasis · correlation 0.73
- Abundant housekeeping transcripts · correlation 0.73
- ER secretory load · correlation 0.69
- Mitochondrial biogenesis · correlation 0.66
- hnRNP mRNA processing · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.