Anaphase Cytokinesis
Gene co-expression module in Smooth muscle cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All eight genes are mitotic/cytokinetic regulators: CDC20 and PTTG1 (APC/C-securin, anaphase onset), ANLN and PRC1 (central spindle/cleavage furrow), CENPF (kinetochore), CCNB2 (mitotic cyclin), CKAP2 and DEPDC1 (spindle-associated). A tight, core module and an essentially redundant partner of M87, splitting the mitotic program into spindle-assembly versus anaphase/cytokinesis phases.
Genes
ANLN, CCNB2, CDC20, CENPF, CKAP2, DEPDC1, PRC1, PTTG1
Most correlated modules
- Mitotic Spindle · correlation 0.98
- Histone Variant Chromatin · correlation 0.89
- Proliferative Biosynthesis · correlation 0.66
- Microfibrillar ECM Program · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.