DEPDC1 — DEP domain containing 1
DEPDC1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEPDC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Kinase Cascade Cell cycle | AURKA, CCNB1, CCNB2, CDC20, CDC25B, FAM72C, FAM72D, KIF20A +6 more | View in SCUBA |
| Smooth muscle cells | Anaphase Cytokinesis Cell cycle | ANLN, CCNB2, CDC20, CENPF, CKAP2, PRC1, PTTG1 | View in SCUBA |
About the gene
| Synonyms | DEP.8, DEPDC1A, FLJ20354, SDP35 |
|---|---|
| Chromosome | 1: 68474152-68497221 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.