ANLN — Anillin, actin binding protein
ANLN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANLN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Spindle Bipolarity Cytokinesis Cell cycle | ARHGAP11A, BUB1B, C21orf58, CIT, DIAPH3, ECT2, KIF11, KIF15 +4 more | View in SCUBA |
| Goblet cells | Chromosome Segregation Cell cycle | CDCA2, CDCA8, CKAP2L, HJURP, KIF11, KIFC1, NCAPG, NDC80 +3 more | View in SCUBA |
| Macrophages | Mitotic Spindle Cell cycle | ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1, CDKN2C +14 more | View in SCUBA |
| Smooth muscle cells | Anaphase Cytokinesis Cell cycle | CCNB2, CDC20, CENPF, CKAP2, DEPDC1, PRC1, PTTG1 | View in SCUBA |
About the gene
| Synonyms | ANILLIN, scra, Scraps |
|---|---|
| Chromosome | 7: 36389821-36453791 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.