Mitotic Spindle
Gene co-expression module in Smooth muscle cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
Textbook G2/M mitotic module: MKI67, UBE2C, AURKB, TPX2, KIF20A, SPC25, SGO1, PIMREG, CDCA3, TOP2A, NUSAP1, CCNA2, CDK1 — kinetochore, spindle and APC/C substrates. Core coherence with all genes core members. Detected in only ~1.6% of cells, consistent with a rare proliferating SMC/mural fraction. Direct neighbor of M51 (cytokinesis) and M83 (histone variants), which together comprise the full cell-cycle program.
Genes
AURKB, CCNA2, CDCA3, CDK1, KIF20A, MKI67, NUSAP1, PIMREG, SGO1, SPC25, TOP2A, TPX2, UBE2C
Most correlated modules
- Anaphase Cytokinesis · correlation 0.98
- Histone Variant Chromatin · correlation 0.91
- Proliferative Biosynthesis · correlation 0.67
- Microfibrillar ECM Program · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.