PRC1 — Protein regulator of cytokinesis 1
PRC1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | G2/M Cell Cycle Cell cycle | CCNF, CDC25C, CDCA3, CDCA8, DEPDC1B, FAM83D, FBXO43, HJURP +1 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CDCA8, CENPE, CENPF, CKS1B, EZH2, MAD2L1 +12 more | |
| Goblet cells | Chromosome Segregation Cell cycle | ANLN, CDCA2, CDCA8, CKAP2L, HJURP, KIF11, KIFC1, NCAPG +3 more | View in SCUBA |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 more | View in SCUBA |
| Smooth muscle cells | Anaphase Cytokinesis Cell cycle | ANLN, CCNB2, CDC20, CENPF, CKAP2, DEPDC1, PTTG1 | View in SCUBA |
About the gene
| Synonyms | ASE1 |
|---|---|
| Chromosome | 15: 90966040-90995629 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division |
Function
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.