Proliferative Biosynthesis
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hubs are classic growth/biosynthetic housekeeping genes: MIF, TUBA1B (tubulin), RHEB (mTORC1 activator), HMGN2 and CBX5 (chromatin), RAN (nucleocytoplasmic transport), SRP9 (SRP), DCTN3/ARF5 (trafficking), DUT/NUCKS1/BUB3 (replication- and mitosis-associated). This is the proliferation-coupled housekeeping/biosynthetic program that typically accompanies cycling cells. Its position as a neighbor of the frank cell-cycle modules M87, M51 and the histone module M83 supports interpretation as the growth/anabolic arm of the proliferative state rather than a distinct signalling program.
Genes
ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2, MIF, NDUFAF3, NUCKS1, PTP4A1, RAN, RHEB, SRP9, TUBA1B
Most correlated modules
- mRNA Splicing Factors · correlation 0.84
- Basal metabolic housekeeping · correlation 0.77
- Microtubule biogenesis · correlation 0.72
- hnRNP & Proteasome · correlation 0.72
- Histone Variant Chromatin · correlation 0.69
- Mitotic Spindle · correlation 0.67
- Anaphase Cytokinesis · correlation 0.66
- Microfibrillar ECM Program · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.