CDC20 — Cell division cycle 20
CDC20 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC20's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDKN3, CENPA, DLGAP5 +7 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Kinase Cascade Cell cycle | AURKA, CCNB1, CCNB2, CDC25B, DEPDC1, FAM72C, FAM72D, KIF20A +6 more | View in SCUBA |
| Goblet cells | G2/M Cyclin Program Cell cycle | ARL6IP1, CCNB1, CCNB2, CENPE, CENPF, CEP55, DLGAP5, HMMR +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | BIRC5, CCNB2, CDKN3, CEP55, DLGAP5, HMMR, MKI67, TPX2 +1 more | |
| Smooth muscle cells | Anaphase Cytokinesis Cell cycle | ANLN, CCNB2, CENPF, CKAP2, DEPDC1, PRC1, PTTG1 | View in SCUBA |
About the gene
| Synonyms | CDC20A, p55CDC |
|---|---|
| Chromosome | 1: 43358981-43363203 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis, Ubl conjugation pathway |
Function
Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20- APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.