MBP — Myelin basic protein
MBP belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Interferon Response Anti-viral | ACAP1, ARHGAP15, BCL2, CD44, CD46, DSE, EML4, FCGR2B +7 more | View in SCUBA |
| Endothelial | Venous EC Identity Endothelial cell development | CAVIN2, CEACAM1, CYBA, DNMBP, EFCC1, EPHX1, GMFG, HID1 +7 more | View in SCUBA |
| Fibroblasts | BMP-antagonizing Fibroblast Developmental | AP1S2, GREM1, HSPB6, IL33, NBEA, PBX3, RGMA, RGN +1 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP +18 more | |
| Innate lymphoid cells | Transcriptional Regulation DNA regulation & transcription | ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
| Natural Killer cells | IFN-stimulated NK Inflammation | AKNA, APOL6, ATM, CTSC, ITGAL, MXD1, PILRB, PTPRC +4 more | View in SCUBA |
About the gene
| Chromosome | 18: 76978827-77133683 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.