TGF-beta Fibrosis
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
LOXL2 crosslinks collagen/elastin and is a canonical fibrosis marker; PLOD1 hydroxylates lysine residues in collagen for crosslinking; FKBP10 is a collagen chaperone required for proper collagen folding; TGFBI is a TGF-beta-induced ECM glycoprotein; PMEPA1 is a direct TGF-beta transcriptional target and feedback regulator; WNT5A promotes fibroblast activation. This is a tightly coherent TGF-beta-driven collagen maturation/fibrosis module, upregulated in both UC and CD inflammation.
Genes
ATP1B3, FKBP10, LOXL2, PLOD1, PMEPA1, SPTSSA, TGFBI, WNT5A
Most correlated modules
- IL-1 Receptor Signaling · correlation 0.89
- Actin Cytoskeletal Organization · correlation 0.88
- Basement Membrane ECM · correlation 0.87
- Hypoxia Response · correlation 0.86
- Lysosomal Stress Response · correlation 0.85
- Wnt-BMP Fibroblast · correlation 0.85
- Actin-Integrin Adhesion · correlation 0.83
- Collagen ECM Production · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.