Wnt-BMP Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
LEF1 is a canonical Wnt/beta-catenin transcription factor; BMP7 is a BMP ligand with anti-fibrotic and developmental roles in the intestine; MFGE8 (milk fat globule EGF factor 8) is a bridging molecule in phagocytosis and tissue homeostasis; GJA1 (Connexin 43) mediates gap junction communication; PXDN (peroxidasin) crosslinks collagen IV in basement membranes; EMID1 is an EMI domain ECM protein; TMOD3 regulates actin filament pointed ends. The combination of LEF1, BMP7, and ECM/structural genes suggests a Wnt/BMP-driven fibroblast homeostasis program associated with remission in UC.
Genes
ABCC4, BMP7, EMID1, ETS1, GJA1, GNG2, LEF1, MFGE8, PAPLN, PCDH18, PTPRM, PXDN, TMOD3, TP53I11
Most correlated modules
- IL-1 Receptor Signaling · correlation 0.85
- TGF-beta Fibrosis · correlation 0.85
- Basement Membrane ECM · correlation 0.84
- Inflammatory Fibroblast Activation · correlation 0.81
- Thrombin Receptor Signaling · correlation 0.81
- Lamina Propria ECM · correlation 0.79
- BMP-Wnt Fibroblast Program · correlation 0.74
- Telocyte Identity Program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.