PLOD1 — Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
PLOD1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLOD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ADAMTS7, ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A +7 more | View in SCUBA |
| Fibroblasts | TGF-beta Fibrosis ECM production | ATP1B3, FKBP10, LOXL2, PMEPA1, SPTSSA, TGFBI, WNT5A | View in SCUBA |
| Gamma-delta T cells | Tissue-resident gd T Tissue residence | AKR1C3, ASCL2, BFSP1, CARNS1, CD320, CES1, CMKLR1, CTBP2 +21 more | |
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1 +7 more | View in SCUBA |
About the gene
| Synonyms | LH1, LLH, PLOD |
|---|---|
| Chromosome | 1: 11934205-11975538 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
Function
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.