Actin-Integrin Adhesion
Gene co-expression module in Fibroblasts
| Category | Migration & adhesion |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include CAP1 (adenylyl cyclase-associated protein, actin dynamics), ACTR2 and ACTR3 (Arp2/3 complex subunits, branched actin nucleation), MSN (moesin, ERM family linking actin to membrane), ITGB1 (integrin beta-1, cell-matrix adhesion), CD151 (tetraspanin, integrin partner), FERMT2 (kindlin-2, integrin activation), and REEP3 (ER shaping). This module is strongly enriched for actin cytoskeleton remodeling and integrin-mediated cell-matrix adhesion machinery. The Arp2/3 complex (ACTR2/ACTR3) and CAP1 drive lamellipodia formation; ITGB1/CD151/FERMT2 anchor cells to ECM. Upregulation in UC/CD inflammation is consistent with fibroblast activation and motility. Neighbor context: M54 (ER folding) and M71 (cytoskeletal/adhesion) support a shared membrane/cytoskeletal neighborhood.
Genes
ACTR2, ACTR3, C5orf24, CAP1, CD151, DEGS1, FERMT2, GNB1, ITGB1, LRP10, MSN, PTTG1IP, RCN2, REEP3
Most correlated modules
- Focal Adhesion ECM · correlation 0.94
- Rho-ROCK Contractility · correlation 0.92
- Actin Cytoskeleton · correlation 0.91
- ER Protein Folding · correlation 0.91
- Actin Cytoskeletal Organization · correlation 0.90
- Inflammatory Fibroblast Activation · correlation 0.88
- Mitochondrial OxPhos · correlation 0.88
- TGF-beta Fibrosis · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.