SCUBA

ATP1B3 — ATPase Na+/K+ transporting subunit beta 3

ATP1B3 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ATP1B3's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsPlasma cell secretory
B cell maturation
AARSD1, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1, MEPCE +9 moreView in SCUBA
CD4⁺ T cellsTCR signaling
TCR/AP1/NFKb pathway
AP3M2, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1, GCSAM +19 moreView in SCUBA
CD8⁺ T cellsCellular Housekeeping
Housekeeping
MRPL13, NUDC, PDAP1, PTBP1, VDAC2, YWHAE, ZCRB1View in SCUBA
EndothelialVascular Tone Regulation
Endothelial cell development
ADAMTS6, ATP1A1, ATP5PF, CALD1, CAVIN3, CCDC3, CD81, HMOX2 +13 moreView in SCUBA
EnterocytesMature colonocyte metabolism
Nutrient metabolism
ANXA4, ASS1, BTNL3, CORO2A, HMCN2, MGAT4A, MOB3B, MTUS1 +6 moreView in SCUBA
FibroblastsTGF-beta Fibrosis
ECM production
FKBP10, LOXL2, PLOD1, PMEPA1, SPTSSA, TGFBI, WNT5AView in SCUBA
Gamma-delta T cellsER Stress Response
Stress
ATP2A2, BACH1, CPD, EIF2AK3, FAM118A, G3BP2, GRK5, HBP1 +13 more
Innate lymphoid cellsNK ILC Tissue Homing
Homing & TEM
ADGRE5, AKAP13, AREG, ARL4C, B3GNT7, BTG1, CCDC107, CCR6 +25 moreView in SCUBA
Lymphatic endothelialNRF2 Oxidative Stress
Stress
F3, GCLM, GRPEL1, HMOX1, PLIN2, SLC3A2, TXNRD1View in SCUBA
MacrophagesNF-κB AP-1 Signaling
Inflammatory
ABL2, AGAP3, ARL8B, ATP6V1H, B4GALT1, C5AR2, CDKN1A, CERT1 +21 moreView in SCUBA
MonocytesMonocyte Immune Tolerance
Tissue adaptation
CTSL, EMP1, FCER1G, FTH1, HAVCR2, INSIG1, MALT1, TIMP1 +1 moreView in SCUBA
PericytesMitochondrial OxPhos
Mitochondrial & OxPhos
ATP5PF, CALM1, CAPZA2, COX17, COX5A, MRPL33, SRP14, TSPOView in SCUBA
Smooth muscle cellsAdhesion Activation
Migration & adhesion
ANXA2, CAPNS1, CD44, CYBRD1, FHL2, LAMC1, LGALS3, LGALS3BP +3 moreView in SCUBA

About the gene

SynonymsCD298, FLJ29027
Chromosome3: 141876124-141926549
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classCD markers, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.