Basement Membrane ECM
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
COL6A1 and COL6A2 encode collagen VI (a major interstitial matrix component); LAMC1 and LAMB1 are laminin gamma-1 and beta-1 chains (basement membrane); ECM1 is a secreted ECM glycoprotein; MMP2 is a matrix metalloproteinase that remodels basement membrane; FNDC3B is a fibronectin domain protein; BSG (basigin/CD147) is an MMP inducer and ECM-associated transmembrane protein. This is a coherent basement membrane and interstitial ECM production module with high expression, consistent with constitutive fibroblast ECM secretion.
Genes
BSG, COL6A1, COL6A2, COMT, ECE1, ECM1, FNDC3B, LAMB1, LAMC1, MMP2, PRICKLE2
Most correlated modules
- Actin Cytoskeletal Organization · correlation 0.90
- TGF-beta Fibrosis · correlation 0.87
- IL-1 Receptor Signaling · correlation 0.86
- Lysosomal Cytoskeletal · correlation 0.85
- Wnt-BMP Fibroblast · correlation 0.84
- Metabolic Homeostasis · correlation 0.82
- Telocyte Identity Program · correlation 0.81
- Thrombin Receptor Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.