Actin Cytoskeletal Organization
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
CAPZB caps actin filament barbed ends; LIMS1 (PINCH-1) is an integrin-linked kinase scaffold protein connecting integrins to actin; SGCB (beta-sarcoglycan) is part of the dystrophin-associated protein complex linking cytoskeleton to ECM; TMEM30A is a phosphatidylserine flippase subunit; DERL1 is an ERAD component; WLS is required for Wnt ligand secretion; ARL3 is a small GTPase involved in vesicle trafficking. The module combines cytoskeletal organization (CAPZB, LIMS1, SGCB) with membrane/secretory housekeeping functions. The cytoskeletal genes dominate by PageRank.
Genes
ACP1, AKR7A2, ARL3, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1, NPTN, SGCB, SLC39A6, SYPL1, TMEM123, TMEM30A, TWSG1, TXNL1, WLS
Most correlated modules
- Metabolic Homeostasis · correlation 0.92
- Proteasome & OxPhos · correlation 0.91
- Actin-Integrin Adhesion · correlation 0.90
- Basement Membrane ECM · correlation 0.90
- ER Protein Folding · correlation 0.89
- IL-1 Receptor Signaling · correlation 0.88
- TGF-beta Fibrosis · correlation 0.88
- Lysosomal Cytoskeletal · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.