RNA Splicing Regulation
Gene co-expression module in Glial cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
This core-coherence module is dominated by RNA splicing regulators: DDX17 (DEAD-box helicase, alternative splicing), PNISR (PNN-interacting serine-rich protein, splicing), LUC7L3 (splicing factor), N4BP2L2 (splicing regulation), ARGLU1 (arginine/glutamate-rich splicing coactivator), ZRANB2 (zinc finger RNA-binding splicing factor). DST (dystonin/BPAG1) is a cytoskeletal linker essential in enteric glia but may be a peripheral member here. SYNE2 (nesprin-2) links cytoskeleton to nuclear envelope. All top hub genes are splicing factors. Neighbor M27 also contains splicing factors (SRSF11, RBM25), confirming this network cluster reflects a glial RNA splicing program.
Genes
ARGLU1, COL16A1, DDX17, DST, LUC7L3, N4BP2L2, NRBP2, PNISR, SYNE2, VPS13C, ZRANB2
Most correlated modules
- Glial Adhesion Cytoskeletal · correlation 0.77
- Peripheral Nerve Myelination · correlation 0.75
- Glial RNA Homeostasis · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.