ZRANB2 — Zinc finger RANBP2-type containing 2
ZRANB2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZRANB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing Regulation RNA processing & translation | CNOT11, CNOT4, CPNE1, CREB1, GATAD1, GTF2A1, LMBRD1, LUC7L3 +10 more | |
| Glial cells | RNA Splicing Regulation RNA processing & translation | ARGLU1, COL16A1, DDX17, DST, LUC7L3, N4BP2L2, NRBP2, PNISR +2 more | View in SCUBA |
| Innate lymphoid cells | Endosomal Trafficking Protein processing & ER | ARL14EP, CCDC90B, CLINT1, ESF1, MDFIC, MDM4, MPHOSPH8, NRIP1 +11 more | View in SCUBA |
| Lymphatic endothelial | Pre-mRNA Splicing RNA processing & translation | ARGLU1, ATRX, BPTF, DDX17, DST, LUC7L3, N4BP2L2, NKTR +6 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
| Neutrophils | mRNA Splicing Processing Housekeeping | ABCA13, ATP2A3, EMB, FBXO9, LUC7L3, NKTR, OGT, PAXBP1 +8 more |
About the gene
| Synonyms | ZIS, ZIS1, ZIS2, ZNF265 |
|---|---|
| Chromosome | 1: 71063291-71081289 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. May interfere with constitutive 5'-splice site selection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.